Parkinson's Disease


Parkinson's Disease has a prevalence of about 200/250 cases per 100,000 inhabitants. We estimate at least 2000 affected people in the province of Padua and about 10,000 in Veneto. Parkinson's Disease is characterized by the slowing down of motor function associated with difficulty in walking, rigidity & agrave; and, at least in two thirds of the cases, genereally with resting tremors.
The disease is due to the loss of dopamine cells in the black substance of the midbrain. The motor symptoms appear after having lost about 50% of the dopaminergic synapses but they can be preceded from many years of non-motor disorders: such as sense of smell degradation, concentration difficulties, apathy and state of mind deflection or constipation. Particularly important are the cognitive disorders they show.
Many patients have a genetic basis and thanks to the Genetics Units of the University Hospital of Padua we have the possibility to provide a comprehensive screening of all the mutations currently involved in the disease by simply taking a blood sample.
Our research activity aims to both: i) indentify new therapeutic strategies to modify the Parkinson's development, such as monoclonal antibodies or drugs that act on genetic causes; and ii) to recognize and treat specific disorders such as cognitive, hallucinations or impulse control disorders.
We are among the first Italian and European centers for deep brain stimulation and infusion therapies.

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     Educational videos

A set of videos on how to manage different aspects of the daily life of people with Parkinon's Disease is available in this section. These videos have been produced during the H2020 European Project PD_Manager”. The aim is to illustrate the symptoms and to provide patients with some good-practice tips. The videos address patients and their families.
Videos were produced by QBGroup srl, the MUSME curator company (Medicine Museum of Padua), and directed by Andrea Marcante, Manuela Giglio e Giovanni Gentile.

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