Multiple System Atrophy


Multiple System Atrophy (MSA) is a rare and progressive disease that affects the cells of the striatum, the nigra substance, the bridge and the cerebellum among other areas of the brain. Clinical symptoms may include parkinsonism, cerebellar ataxia and autonomic dysfunction in various combination. Based on the predominance of parkinsonian or cerebellar symptoms they are classified respectively in the MSA-P or MSA-C subtype. The average age at onset of motor symptoms is between 50 and 60 years without any difference in the distribution of sex. The autonomic dysfunctions concern the cardiovascular, respiratory and urogenital functions (urgency and retention). Furthermore, a disturbance of the sleep behavior with rapid eye movement (RBD) is frequently observed in the premotor phase. The MSA generally occurs sporadically.

In addition to traditional therapeutic approaches, our center works with international groups to develop innovative treatments.

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